Continuously updated · last reviewed Sep 5, 2026
Each page covers one condition properly: what it actually is and what it feels like, what causes it, how common it really is and in whom, and how it's diagnosed — followed by the specific variants with a replicated link to it, and, where the research supports it, how genetics can change the way a medicine behaves.
Written in two registers so one page serves both readers: plain language first, then a clinical detail section with the precise terminology, effect sizes and diagnostic thresholds. Every claim is sourced from freely-available published research and cited on the page, so you can check us — or hand the page to your doctor. 27 conditions so far, growing continuously, and free to reuse with attribution (CC BY 4.0).
5 results in Metabolic
A common East Asian genetic variant that leaves the body unable to fully break down a toxic alcohol byproduct, causing facial flushing and, with regular drinking, a substantially elevated risk of esophageal cancer.
Read more → MetabolicAn inherited condition in which the body absorbs more iron from food than it needs. Over decades the surplus iron can build up in the liver, heart, pancreas and joints and cause damage.
Read more → MetabolicWhether you can comfortably drink milk as an adult comes down largely to a single DNA switch near the LCT gene. Persistent lactase activity is the evolutionary exception in humans, not the default.
Read more → MetabolicTwo very common MTHFR variants modestly change how efficiently one folate-processing enzyme works. They are heavily over-claimed online; here is what the published evidence actually supports, and what it does not.
Read more → MetabolicA common variant near the FTO gene is linked to a small average increase in body weight and BMI by nudging appetite regulation. Most carriers never become obese — environment and behavior still matter most.
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