Sensitive

Warfarin sensitivity

VKORC1 · rs9923231

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Where this position leads

Condition: Warfarin Sensitivity and Anticoagulant Dose Variability

Drug: Warfarin

rs9923231 Condition: Warfarin Sensitivity and Anticoagulant Dose Variability Warfarin Sensitivity and Anticoagulan… Condition Drug: Warfarin Warfarin Drug rs9923231 VKORC1

What each result means

C/C Published research associates this genotype with typical VKORC1 expression and standard warfarin dosing requirements.
C/T Published research associates this genotype with reduced VKORC1 expression, associated with needing a lower-than-average warfarin dose to reach the same anticoagulation effect.
T/T Published research associates this genotype with substantially reduced VKORC1 expression, associated with needing a markedly lower warfarin dose. Starting at a standard dose without accounting for this genotype is associated with elevated bleeding risk during the initial treatment period.
This is a pharmacogenomic finding with clinical dosing guidelines (CPIC). If you are prescribed warfarin, share this result with your doctor — dosing algorithms that incorporate VKORC1 (and CYP2C9) genotype are standard practice. Do not adjust any medication on your own.

Source: Rieder et al. 2005, New England Journal of Medicine — effect of VKORC1 haplotypes on transcription and warfarin dose.

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