Standard

Lactose tolerance

MCM6 / LCT · rs4988235

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Where this position leads

Condition: Lactose Intolerance (Lactase Persistence)

rs4988235 Condition: Lactose Intolerance (Lactase Persistence) Lactose Intolerance (Lactase Persistence) Condition rs4988235 MCM6 / LCT

What each result means

C/C Two copies of the ancestral allele. Published research associates this genotype with lactase non-persistence — lactase production typically declines after childhood, which can mean reduced tolerance for dairy in adulthood.
C/T One copy of each allele. Research associates this genotype with a good chance of continued lactase production into adulthood, though individual tolerance still varies.
T/T Two copies of the derived allele. Published research associates this genotype with lactase persistence — continued lactase production into adulthood is common.
Lactose tolerance in practice depends on more than one gene and can change over time. If dairy causes discomfort, talk to a doctor before changing your diet.

Source: Enattah et al. 2002, Nature Genetics — identification of a variant associated with adult-type hypolactasia.

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