Sensitive

CYP2C19 *3 — clopidogrel activation

CYP2C19 · rs4986893

Where this position leads

Drug: Clopidogrel

rs4986893 Drug: Clopidogrel Clopidogrel Drug rs4986893 rs4986893 CYP2C19

What each result means

A/A Two copies of CYP2C19*3 — no functioning enzyme from this position, with the same consequence for clopidogrel as two copies of *2.
A/G One copy of CYP2C19*3, a no-function allele. It does the same thing as *2 and is found more often in east Asian populations, which is why a CYP2C19 panel that tests only *2 misclassifies more people there.
G/G No copy of *3 at this position.
This is a pharmacogenomic result with a published dosing guideline behind it. Tell a prescriber or pharmacist rather than acting on it — and never stop or change a prescribed medicine on the strength of a genotype.

Source: CPIC Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update, Clinical Pharmacology & Therapeutics (PMID 35034351).

Questions about rs4986893

What is rs4986893?

rs4986893 is a single position in the genome, in or near the CYP2C19 gene. Published research associates it with cyp2c19 *3 — clopidogrel activation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs4986893 affect how medicines work?

CYP2C19 carries pharmacogenomic findings for Clopidogrel. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

Does having rs4986893 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4986893 come from?

CPIC Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update, Clinical Pharmacology & Therapeutics (PMID 35034351). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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