A/ATwo copies of CYP2C19*2, so no functioning enzyme from this position. Poor metabolisers form much less of clopidogrel's active metabolite; CPIC recommends an alternative antiplatelet drug where there is no contraindication to one.
A/GOne copy of CYP2C19*2, an allele with no enzyme function. Clopidogrel is a prodrug: CYP2C19 is what turns it into the molecule that actually stops platelets sticking. Carriers of one no-function allele are usually intermediate metabolisers, and CPIC reports reduced platelet inhibition and increased risk of major adverse cardiovascular and cerebrovascular events on clopidogrel.
G/GNo copy of *2 at this position. This is the working version of the enzyme here, though other CYP2C19 alleles exist and a full phenotype needs more than one position.
This is a pharmacogenomic result with a published dosing guideline behind it. Tell a prescriber or pharmacist rather than acting on it — and never stop or change a prescribed medicine on the strength of a genotype.
Source: CPIC Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update, Clinical Pharmacology & Therapeutics (PMID 35034351).
Questions about rs4244285
What is rs4244285?
rs4244285 is a single position in the genome, in or near the CYP2C19 gene. Published research associates it with cyp2c19 *2 — clopidogrel activation. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.
Does rs4244285 affect how medicines work?
CYP2C19 carries pharmacogenomic findings for Clopidogrel. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.
Does having rs4244285 mean I will get this?
No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.
Where does the information about rs4244285 come from?
CPIC Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update, Clinical Pharmacology & Therapeutics (PMID 35034351). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.