Standard

Smoking behavior

CYP2A6 · rs4105144

Where this position leads

Drug: Smoking cessation medicines

rs4105144 Drug: Smoking cessation medicines Smoking cessation medicines Drug Topic: Smoking and vaping Smoking and vaping Topic rs4105144 rs4105144 CYP2A6

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Smoking behavior compared to the general population. (GWAS Catalog, Nat Genet 2010, PMID:20418888)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Smoking behavior. (GWAS Catalog, Nat Genet 2010, PMID:20418888)
T/T Published research associates this genotype with typical/baseline likelihood of Smoking behavior — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2010, PMID:20418888)

Source: GWAS Catalog, Nat Genet 2010, PMID:20418888

What people read about alongside this

Smoking and vaping4

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs4105144

What is rs4105144?

rs4105144 is a single position in the genome, in or near the CYP2A6 gene. Published research associates it with smoking behavior. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs4105144 affect how medicines work?

CYP2A6 carries pharmacogenomic findings for Smoking cessation medicines. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

What do people read about alongside rs4105144?

Subjects that appear in the title or abstract of the same papers as this rsID include smoking and vaping (4 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs4105144 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs4105144 come from?

GWAS Catalog, Nat Genet 2010, PMID:20418888. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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