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Duffy blood group (malaria resistance)

DARC / ACKR1 · rs2814778

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Where this position leads

Condition: Duffy-Null Phenotype and Benign Ethnic Neutropenia

rs2814778 Condition: Duffy-Null Phenotype and Benign Ethnic Neutropenia Duffy-Null Phenotype and Benign Ethni… Condition rs2814778 DARC / ACKR1

What each result means

C/C Published research associates this genotype with typical Duffy antigen expression on red blood cells.
C/T One copy of the variant. Published research associates this genotype with reduced Duffy antigen expression.
T/T Published research associates this genotype with absence of the Duffy antigen on red blood cells (the "Duffy-null" phenotype) — this is common in populations of West African ancestry and is associated with natural resistance to Plasmodium vivax malaria infection, since that parasite uses the Duffy antigen to enter red blood cells.

Source: Miller et al. 1976, New England Journal of Medicine — the Duffy blood group phenotype and resistance to Plasmodium vivax malaria.

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