Sensitive

Myocardial infarction (early onset)

CXCL12 · rs1746048

Where this position leads

Condition: Coronary Artery Disease

rs1746048 Condition: Coronary Artery Disease Coronary Artery Disease Condition rs1746048 rs1746048 CXCL12

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Myocardial infarction (early onset) compared to the general population. (GWAS Catalog, Nat Genet 2009, PMID:19198609)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Myocardial infarction (early onset). (GWAS Catalog, Nat Genet 2009, PMID:19198609)
T/T Published research associates this genotype with typical/baseline likelihood of Myocardial infarction (early onset) — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2009, PMID:19198609)

Source: GWAS Catalog, Nat Genet 2009, PMID:19198609

What people read about alongside this

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1746048

What is rs1746048?

rs1746048 is a single position in the genome, in or near the CXCL12 gene. Published research associates it with myocardial infarction (early onset). A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1746048 linked to?

On MyGeneLog this position is linked to Coronary Artery Disease. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1746048?

Subjects that appear in the title or abstract of the same papers as this rsID include alcohol and the flush (1 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1746048 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1746048 come from?

GWAS Catalog, Nat Genet 2009, PMID:19198609. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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