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Obesity

FTO · rs1421085

Where this position leads

Condition: Obesity and Body Weight

rs1421085 Condition: Obesity and Body Weight Obesity and Body Weight Condition Topic: Exercise and muscle Exercise and muscle Topic Topic: Sleep and insomnia Sleep and insomnia Topic Topic: Depression and stress Depression and stress Topic rs1421085 rs1421085 FTO

What each result means

C/C Published research associates this genotype (two copies of the reported risk allele) with a higher likelihood of Obesity compared to the general population. (GWAS Catalog, Nat Genet 2013, PMID:23563607)
C/T Published research associates this genotype (one copy of the reported risk allele) with an intermediate association with Obesity. (GWAS Catalog, Nat Genet 2013, PMID:23563607)
T/T Published research associates this genotype with typical/baseline likelihood of Obesity — no copies of the reported risk allele. (GWAS Catalog, Nat Genet 2013, PMID:23563607)

Source: GWAS Catalog, Nat Genet 2013, PMID:23563607

What people read about alongside this

Exercise and muscle15 Sleep and insomnia5 Depression and stress4 Alcohol and the flush3 Brain and memory2 Risk-taking and impulsivity1 Caffeine and energy drinks1

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs1421085

What is rs1421085?

rs1421085 is a single position in the genome, in or near the FTO gene. Published research associates it with obesity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

What conditions is rs1421085 linked to?

On MyGeneLog this position is linked to Obesity and Body Weight. The research behind each link, and its sources, are set out on that condition page.

What do people read about alongside rs1421085?

Subjects that appear in the title or abstract of the same papers as this rsID include exercise and muscle (15 papers), sleep and insomnia (5 papers), depression and stress (4 papers), alcohol and the flush (3 papers), brain and memory (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs1421085 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs1421085 come from?

GWAS Catalog, Nat Genet 2013, PMID:23563607. Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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