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Freckling & sun sensitivity

IRF4 · rs12203592

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Where this position leads

Condition: Sun Sensitivity, Freckling and Skin Cancer Risk

rs12203592 Condition: Sun Sensitivity, Freckling and Skin Cancer Risk Sun Sensitivity, Freckling and Skin C… Condition rs12203592 IRF4

What each result means

C/C Typical IRF4 activity in published research — no added association with freckling from this variant.
C/T One copy of the variant. Published research associates this genotype with a somewhat higher likelihood of freckling and sun sensitivity.
T/T Published research associates this genotype with a meaningfully higher likelihood of freckling, lighter skin/hair pigmentation, and increased sun sensitivity.
Regardless of genotype, sun protection habits matter — this variant is about likelihood of freckling, not a substitute for skin-cancer screening advice from a doctor.

Source: Han et al. 2008, PLOS Genetics — a genome-wide association study identifies novel alleles associated with hair color and skin pigmentation.

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