UTC
Standard

CYP2C19 *17 — increased enzyme activity

CYP2C19 · rs12248560

Where this position leads

Drug: Clopidogrel

rs12248560 Drug: Clopidogrel Clopidogrel Drug rs12248560 rs12248560 CYP2C19

What each result means

C/C No copy of *17.
C/T One copy of CYP2C19*17, a promoter variant associated with increased enzyme activity rather than less. It sits on the other side of the same dial: more activation of prodrugs such as clopidogrel, and faster clearance of drugs the enzyme inactivates.
T/T Two copies of CYP2C19*17 — the ultrarapid end of the range. Guidelines treat this as normal-to-increased for clopidogrel; where it matters more is for drugs CYP2C19 breaks down rather than switches on.
This is a pharmacogenomic result with a published dosing guideline behind it. Tell a prescriber or pharmacist rather than acting on it — and never stop or change a prescribed medicine on the strength of a genotype.

Source: CPIC Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update, Clinical Pharmacology & Therapeutics (PMID 35034351).

What people read about alongside this

Depression and stress2

Papers in Europe PMC whose title or abstract names both this rsID and that subject. A shared paper means somebody wrote about the two together — it is not a claim that this position explains the subject.

Questions about rs12248560

What is rs12248560?

rs12248560 is a single position in the genome, in or near the CYP2C19 gene. Published research associates it with cyp2c19 *17 — increased enzyme activity. A single variant does not decide an outcome — it shifts a probability, and for most common variants the shift is small.

Does rs12248560 affect how medicines work?

CYP2C19 carries pharmacogenomic findings for Clopidogrel. That is educational information, not a prescription or a dosing guide. Any decision to start, stop or change a medicine belongs with the clinician or pharmacist managing your treatment.

What do people read about alongside rs12248560?

Subjects that appear in the title or abstract of the same papers as this rsID include depression and stress (2 papers). A shared paper means somebody wrote about the two together; it is not a claim that this position explains the topic.

Does having rs12248560 mean I will get this?

No. Common variants like this one move a probability slightly and, on their own, rarely decide anything about one person. Nothing on this page is a diagnosis, and health decisions should be made with a clinician who can see your whole picture.

Where does the information about rs12248560 come from?

CPIC Guideline for CYP2C19 Genotype and Clopidogrel Therapy: 2022 Update, Clinical Pharmacology & Therapeutics (PMID 35034351). Every variant on MyGeneLog comes from public primary sources and is published with its citation and the date it was checked.

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